Expression and Immunogenicity Determination of Recombinant Clone of Pasteurella multocida Serotype B Against Haemorrhagic Septicaemia: Towards a Vaccine Development
نویسندگان
چکیده
منابع مشابه
Pathogenicity and immunogenicity of native and mutant strains of Pasteurella multocida, the causative agents of haemorrhagic septicaemia
Haemorrhagic septicaemia (HS) is a fatal systemic disease of cattle and buffaloes. Some control isachieved with administration of alum-precipitated or oil-adjuvanted killed whole-cell vaccines injectedsubcutaneously. These vaccines, however, provide only short-term immunity and for effective use, theyshould be administered annually. We constructed an aroA attenuated derivative of a Pasteurella ...
متن کاملEvaluation of immunogenicity and protective efficacy of recombinant ptfA of avian Pasteurella multocida
Avian Pasteurella multocida is the causative agent of fowl cholera, a disease much affecting the poultry industry. In order to study the efficacy of the recombinant subunit vaccine constructed with ptfA gene of avian P. multocida, the ptfA gene fragment amplified by PCR from avian P. multocida was cloned into the prokaryotic expression vector pET32a and the recombinant plasmid pET32a-ptfA was o...
متن کاملNew sites of localisation of Pasteurella multocida B:2 in buffalo surviving experimental haemorrhagic septicaemia
BACKGROUND Haemorrhagic septicaemia (HS) is an acute septicaemic disease of buffalo and cattle caused by Pasteurella multocida B:2 and E:2. Field outbreaks of HS are known to result in localisation of bacteria in the tonsils of surviving buffalo, confirming that animals can become carriers and the role of respiratory tract in the transmission of the disease. This report describes additional sit...
متن کاملPasteurella multocida P52 aroA mutant conferred protection to rabbits and mice against haemorrhagic septicaemia
Pasteurella multocida serotype B:2 is the etiological agent of haemorrhagic septicaemia (HS) in cattle and buffaloes, a disease that causes significant economic losses to the dairy industry in India. Several killed vaccines are in uses that provide protection to limited period of time. The aim of this study was to generate an attenuated strain of Pasteurella multocida P52 by targeted gene knock...
متن کاملpathogenicity and immunogenicity of native and mutant strains of pasteurella multocida, the causative agents of haemorrhagic septicaemia
haemorrhagic septicaemia (hs) is a fatal systemic disease of cattle and buffaloes. some control isachieved with administration of alum-precipitated or oil-adjuvanted killed whole-cell vaccines injectedsubcutaneously. these vaccines, however, provide only short-term immunity and for effective use, theyshould be administered annually. we constructed an aroa attenuated derivative of a pasteurella ...
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ژورنال
عنوان ژورنال: Journal of Animal and Veterinary Advances
سال: 2012
ISSN: 1680-5593
DOI: 10.3923/javaa.2012.351.356